In order to present effectively the function of irony and its relation to the spirit of Humanism, we will use Erasmus’ work Moriae Encomium. Erasmus knew Latin and ancient Greek and studied classical and biblical literature. He maintained personal contact with many scholars of his time, traveling frequently and exchanging letters. Although he was a clergyman, his main occupation was the translation of ancient sources, the editing and the new edition of classical and biblical literature, and the production of pedagogical and didactic works. All of the above make him a typical representative of the Humanistic spirit. However, "despite his rigorous literary work, he often wrote in a very sharp critical or satirical tone, cultivating particular irony"